• Users Online: 183
  • Print this page
  • Email this page
Year : 2021  |  Volume : 4  |  Issue : 2  |  Page : 118-123

Valporic acid-induced hepatotoxicity in rats: Protective effect of selenium

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Bayelsa State, Nigeria
2 Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, Rivers State, Nigeria

Correspondence Address:
Elias Adikwu
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Bayelsa State
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jnsm.jnsm_123_20

Rights and Permissions

Background: The use of valproic acid (VPA) as therapy for epileptic and other neuropsychiatric disorders may cause hepatotoxicity. Selenium (Se), a component of selenoproteins, which performs important enzymic functions, may protect biomolecules from damage. This study assessed the protective effect of Se against VPA-induced hepatotoxicity in Wistar rats. Methods: Thirty-two adult Wistar rats of both sexes (160 ± 20 g) were divided into four groups of n = 8. Groups 1 (Control), 2, and 3 were orally administered with normal saline (0.2 mL), Se (0.1 mg/kg/day), and VPA (200 mg/kg/day) for 30 days, respectively. Group 4 was orally administered with Se (0.1 mg/kg/day) and VPA (200 mg/kg/day) for 30 days. After treatment, the rats were weighed and anesthetized. Blood samples were collected and analyzed for serum biochemical parameters. Liver samples were weighed and assessed for biochemical markers and histology. Results: Body weight was significantly (P < 0.01) decreased, whereas liver weight was significantly (P < 0.01) increased in VPA administered rats. VPA caused significant (P < 0.001) increases in serum and liver aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, conjugated bilirubin, total bilirubin, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and malondialdehyde levels when compared to control. VPA produced significant (P < 0.001) decreases in liver glutathione, catalase, superoxide dismutase, glutathione peroxidase and serum high density lipoprotein cholesterol levels when compared to control. Hepatocyte necrosis and fatty change were observed in VPA- administered rats. Se supplementation significantly (P < 0.01) reversed VPA-induced hepatotoxicity. Conclusion: Se seems effective against VPA-induced hepatotoxicity.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal