• Users Online: 82
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 4  |  Page : 344-355

2020 Updates on tocilizumab indications for clinicians managing patients with severe acute respiratory syndrome coronavirus 2


1 Rheumatology Unit, Department of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Rheumatology unit, Department of Medicine, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
3 Rheumatology Unit, Department of Medicine, University of Jeddah, Jeddah, Saudi Arabia
4 Department of Clinical Pharmacy, King Saud University Medical City, Riyadh, Saudi Arabia
5 Pediatric Rheumatology Unit, Department of Pediatric, King Abdullah Specialized Children Hospital, Riyadh, Saudi Arabia
6 Infectious Disease Unit, Department of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Mohammed A Omair
Rheumatology Unit, Department of Medicine, King Saud University, 38, PO Box 2925, Riyadh 11461
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JNSM.JNSM_85_20

Rights and Permissions

In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, as a global pandemic. The number of infected individuals has grown exponentially, and no vaccine candidate is currently available. Hence, various drugs are being considered for the treatment of patients with COVID-19. Tocilizumab, a novel humanized monoclonal antibody targeting interleukin-6 (IL-6) receptor, has been approved for the treatment of various inflammatory conditions, including moderate-to-severe rheumatoid arthritis, giant cell arteritis, active polyarticular and systemic juvenile idiopathic arthritis in patients aged ≥2 years, and Castleman disease. Given that patients with severe COVID-19 show features of an accentuated immune response and increased release of many proinflammatory cytokines, including IL-6, tocilizumab has been repurposed as a possible COVID-19 therapy. This review provides clinicians managing patients with COVID-19 with an overview of the IL-6 pathway, its blockade by tocilizumab, and the effects of this drug in various inflammatory conditions, including current understanding of its effects in patients with COVID-19. Tocilizumab is listed as an option for treating severe or critical cases of COVID-19 with elevated IL-6 in the 7th edition of the National Health Commission of the People's Republic of China COVID-19 Diagnosis and Treatment Guide. A systematic review of six small observational studies and case reports on the supportive use of tocilizumab in patients with COVID-19 suggested some benefits of the treatment but did not allow solid conclusions; further clinical trials are currently evaluating the impact of adding tocilizumab to the treatment regimen for these patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed143    
    Printed0    
    Emailed0    
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal