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ORIGINAL ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 4  |  Page : 262-266

The role of thiol–disulfide and ischemia-modified albumin in the differential diagnosis of ovarian pathologies in children


1 Department of Pediatric Surgery, Ankara Yildirim Beyazit University, Ankara, Turkey
2 Department of Biochemistry, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey
3 Pediatric Surgery Clinic, Ankara City Hospital, Ankara, Turkey
4 Pediatric Clinic, Ankara City Hospital, Ankara, Turkey
5 Department of Pediatric Surgery, Yildirim Beyazit University, Ankara, Turkey

Correspondence Address:
Can Ihsan Oztorun
İrfan Baştuğ Avenue, Kurtdereli Street, Altindağ, Ankara 06130
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JNSM.JNSM_8_20

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Introduction: The aim of this study was to evaluate the association between ovarian pathologies and oxidative stress in children via the new method of thiol/disulfide homeostasis. Materials and Methods: The study was conducted in our clinic and included 24 cases of ovarian cysts (OCs) followed by us and 23 cases of operated OC or torsion and monitored by pediatric surgical intensive care unit. The control group consisted of 24 girls who admitted to the pediatric surgery outpatient clinic because of not-incarcerated inguinal hernia. Serum native thiol, total thiol, dynamic disulfide, albumin, and ischemia-modified albumin (IMA) levels of the patients and healthy volunteers were evaluated. Results: Native thiol (P = 0.41), total thiol (P = 0.57), dynamic disulfide (P = 0.98), albumin (P = 0.54), and IMA (P = 0.98) levels of the patients with OC were found similar with the ovarian torsion (OT) group. However, there were statistically significant differences in native thiol (P < 0.001), total thiol (P < 0.001), albumin (P < 0.001), and IMA (P < 0.001) levels of OT group compared to the controls, whereas dynamic disulfide levels (P = 0.63) were not statistically different from that of controls. Conclusions: In children, the evaluation thiol/disulfide homeostasis might be helpful in the diagnosis of ovarian pathology. Nonetheless, it could not be helpful in the differential diagnosis of OT, which requires emergency surgery from the other ovarian pathologies. Measuring of IMA levels as well as thiol/disulfide homeostasis could increase the specificity of the test. Further studies with larger samples are needed to clarify this issue.


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