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Association of galectin-3 and hypoxia-inducible factor-1α with progression of oral squamous cell carcinoma

 Department of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt

Correspondence Address:
Gihan Adel Balbola,
7321, Airport Devision, Gizan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JNSM.JNSM_48_18

Background: Oral squamous cell carcinoma (OSCC) represents more than 90% of all malignancies of the head and neck. Some biochemical and molecular changes in cells precede the establishment of neoplasms, and in this case, the deregulation of various proteins, such as hypoxia-inducible factor-1 and galectins-3 can strongly influence tumor progression through their effects on immunological surveillance, angiogenesis, cell migration, adhesion and cellular response to chemotherapy. Objective: In this study we investigated the association of both HIF-1α and galectin-3 in oral carcinogen. Materials and Methods: Five cases of normal oral epithelial tissues, 15 cases of severe epithelial dysplasia and 40 cases of different grades of OSCC were collected. Immunohistochemical staining for HIF-1α and galectin-3 antibodies were done for all specimens. Results: For both antibodies, statistically, the greatest mean area percent was recorded OSCC, whereas the lowest values were recorded in normal tissue. Conclusions: These results confirm that there is a dynamic regulation of galectin-3 in response to the tumor microenvironment associated hypoxia.

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